What is it:
Ozone is a gas or O3. It is formed from oxygen and it is a strong oxidant and very reactive.
Is it safe when used medically with medical grade oxygen:
Yes! Used appropriately at the right dose and concentration, ozone therapy is very safe. The reason ozone is not safe in the atmosphere is because it is at the wrong concentration, but do to its nature, it is highly reactive and will react with other molecules in the atmosphere.
Ozone therapy has been used for over 100 years in medicine and is being used currently in numerous countries around the world to treat diseases. It has been used to sterilize surgical instruments, operating rooms and wounds. In 1936, a physician published a paper about its use in treating colitis and fistulas. The big break through came when we learned the appropriate concentration and dose to deliver to patients. It was discovered that mild oxidative stress induces numerous therapeutic and critical things in the body.
How can it be given safely to treat patients:
It must be pure, given at the right concentration and dose, which will change based on the disease being treated, the desired effects and the route of administration: You should see a physician that has been certified and been through training courses!
Water and oils can be ozonated. These can be consumed or applied topically. (We do use ozonated oils at times)
Ozone Steam Chamber: Helps detoxify the blood, lymphatics and will get ozone into the body. The heat will amplify the effects and help with NAD+ and detoxification. (We use this method and have a chamber)
Intestinal Insufflation: This is great for Intestinal issues and liver issues, but the ozone will also go systemic or impact other organs in the body. It is often used to treat Hepatitis, Hepatitis B and C, Fatty Liver disease and Crohn’s and ulcerative colitis….. (We use this method in our practice and dispense ozone bags, so people can do it at home).
Major Autohemotherapy (MAH): This treats systemic illness.
Infections: Lyme, protozoan, viral ie) Hepatitis C and B, Herpes, HIV as an adjunct, candidiasis or fungal infections. It helps break up biofilms and penetrates areas that pathogens hide.
It can be used to assist a patient in fighting cancer and will induce Interferon, increase Natural killer Cells and Alters Lymphocyte activity……
Neurodegenerative Diseases such as Parkinson’s disease, Dementia, Multiple Sclerosis (MS) (80-90% remission rate and reversal of symptomsin 6-12 weeks using the Simonetti Protocol) and ALS.
Glaucoma and Macular Degeneration
Vascular Diseases and can promote the release of VEGF, a chemical needed to grow new blood vessels.
Helps dissolve Endometiosis or abnormal endometrial tissue in the body
It can help sexual disfunction
Many more diseases
Vaginal Insufflation: and treatment of interstitial cystitis
Injection or Prolozone in a liquid to promote joint healing and treat pain. It can also help hair growth and can be very beneficial when combined with Platelet Rich Plasma or used along with Stem Cell Therapy (We provide this at our office)
How it works and what is the magic:
At the right dose a little oxidative stress induces amazing things in the body! Too much is inflammatory, but a low amount can crush inflammation.
It induces NRF2, which will maintain and release stem cells. This may explain the impact on joints when injected.
NRF2 causes an increase in enzymes that scavenge and inactivate free radicals or oxidants that harm the body. Superoxide Dismutase, Catalase, and enzymes responsible for Glutathione production all increase. The body can inactivate Hydrogen Peroxide……and get rid of harmful chemicals and metals.
Heme Oxygenase 1 and 2, 3 DPG increase and this results in more oxygen being delivered to organs, tissues and cells. Oxygen is critical for life, healing and health.
Ozone reduces the amount of NADH and increases the amount of NAD+ in the body. As we age, NADH goes up and NAD declines. NAD+ allows us to repair DNA, release Stem Cells and depleted by most diseases. Increasing NAD is anti-inflammatory and protects our bodies and modifies the immune system. It also regulates Sirtuins and these play a critical in numerous diseases and diabetes.
Ozone activates HIF-1a and this is probably one reason why ozone is helpful with vascular diseases.
Nuclear Factor of Activated T-cells (NFAT) increases and so does Activated Protein 1 (AP-1) and this helps modulate the immune response. It modifies numerous cells the immune system uses to fight disease.
Ozone will help eradicate irregular proteins.
It modifies the releases of INF gamma, IL-1, IL-2, IL-6, TNF alpha and IL-8. It will down regulate NFKB and COX-2, which is involved in inflammation, many diseases and cancer.
It helps the production of ATP and helps the Krebs Cycle and the electron transport chain involved in the production of ATP or cellular energy.
Ozone modifies Nerve Growth Factor (NGF) Release and Brain Derived Neurotrophic Factor (BDNF) Release, These are needed to maintain a healthy nervous system and form connections between nerves.
Finally, it modifies PDGF and TGFB1 along with many enzymes……..
As a dirty rule of thumb, lower doses tend to be more activating and higher doses tend to be more suppressive.
Used correctly and with other modalities, ozone is truly amazing.